People

Simon F. Roy, MD, MHS, is a clinician-scientist and dermatopathologist at McGill University. He is an Assistant Professor in the Division of Dermatopathology, Department of Pathology, and a principal investigator at both the Rosalind and Morris Goodman Cancer Institute and the Research Institute of the McGill University Health Centre.

Dr. Roy’s research program focuses on melanoma immunobiology, with particular attention to acral and mucosal melanomas. His laboratory combines analysis of patient tissue with digital pathology, spatial multiomics, machine learning, live imaging, organotypic precision-cut tumor slice cultures, and mouse models. This translational framework is designed to reveal how tumor and immune cells change during therapy, test candidate treatments in living tissue, and identify strategies to overcome resistance.

Dr. Roy completed postdoctoral research training in the Bosenberg Laboratory at Yale University from 2022 to 2025. There, he studied melanoma immunobiology, spatial transcriptomics, ferroptosis, and patient-derived models of immunotherapy response. He also completed a Master of Health Science and clinical fellowship training in dermatopathology at Yale.

In his clinical work, Dr. Roy studies inflammatory and neoplastic diseases of the skin, including melanoma. He is the lead melanoma pathologist for the Core Molecular and Diagnostics Laboratory and FRQS Precision Oncology Co-Lead at the Goodman Cancer Institute. He also leads an international rare skin cancer biobank based at the McGill University Health Centre.

This combination of clinical pathology and experimental research keeps the lab closely connected to patient needs. Questions observed in diagnostic practice inform research, and findings from the laboratory are developed toward biomarkers, therapeutic hypotheses, preclinical drug studies, and early-phase clinical investigation.